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Search Results for " huntington’s disease "

11

Compounds

Cat No. Product Name Synonyms Targets
T36036 CAY10786 GPR52 antagonist-1 GPR
CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
T0719 Tetrabenazine Xenazine,Ro 1-9569 Others , Dopamine Receptor , Monoamine Transporter
Tetrabenazine (Ro 1-9569) is a drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high...
T39479 Rovanersen WVE-120101,Rovanersen
Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntingtons disease research.
T26878 BN-82451 HCl BN 82451B,BN 82451,BN-82451,BN82451B,BN-82451B,BN82451
BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntingtons disease.
T39166 Tominersen IONIS-HTTRx,RG6042
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen can be used for the research of Hun...
T60824 Dyrk1A-IN-3
Dyrk1A-IN-3 (Compound 8b) is a highly selective inhibitor of dual-specificity tyrosine-regulated kinase 1A (DYRK1A). Dyrk1A-IN-3 has high binding affinity of DYRK1A with an IC 50 of 76 nM. Dyrk1A-IN-3 can be used in neur...
T74881 FITC-labeled Tominersen
FITC-labeled Tominersen is Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT p...
T73683 AC-VEID-CHO TFA
AC-VEID-CHO (TFA) is a peptide-derived inhibitor targeting Caspases-6, -3, and -7, exhibiting IC50 values of 16.2 nM, 13.6 nM, and 162.1 nM, respectively. This compound demonstrates significant inhibitory potency and is ...
T61063 SEN177
SEN177 shows the potential in the research of Huntingtons disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). The Ki value of SE...
T37791 A-971432
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cel...
T83669 PMX-53 TFA AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53
PMX-53, a macrocyclic complement 5a (C5a) peptidomimetic and C5a receptor antagonist (IC50 = 0.3 µM), effectively inhibits the C5a-induced secretion of myeloperoxidase (MPO) in isolated human polymorphonuclear leukocytes...
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